RestoriX is a daily supplement designed to support energy levels.
Our human body is made up of trillions of cells. They are the basic building blocks of life. Cells have specific tasks to perform and they work together to enable the body to meet its basic needs. These cellular processes require energy to function. However, as we age, cellular energy production in our body decreases(1).
WHAT IS NAD+?
Nicotinamide adenine dinucleotide (NAD+) is a coenzyme that is present naturally in every cell of our body and is essential to life. It is nicknamed 'the molecule of youth' due to its role in cellular energy production and its ability to regulate the genes of aging1. Unfortunately, as we grow older, the NAD+ levels in our body declines(1).
RestoriXTM contains nicotinamide which is a precursor of NAD+ to boost the NAD+ cellular levels in the body.
SUPPORT ENERGY PRODUCTION
Mitochondria are powerhouses of our cells. They are empowered by NAD+ in the production of cellular energy for the sustenance of life. As the level of NAD+ declines with age, mitochondria function is impaired which results in reduced amount of surviving healthy mitochondria(2). This vicious cycle of the depletion of mitochondria which results in metabolic energy deficiency is evident in the physical symptoms of aging such as chronic fatigue and weakness. NAD+ is crucial in the maintenance of functional mitochondria in preserving cellular energy reserve.
Sirtuins are enzymes that have the ability to regulate the genes of aging(3). These enzymes are dependent on NAD+ for their function as NAD+ directly activates them to switch off genes that promote aging(4,5). Resveratrol and quercetin also assist with the proper functioning of sirtuins.
DNA CELL REPAIR
Poly-ADP-ribose polymerase-1 (PARP-1) is an enzyme that detects DNA damage and initiates DNA repair(6). The function of PARP-1 is important as the accumulated replication of damaged DNA would lead to progressive functional decline in many tissues in our body which contributes to the process of aging(6). For PARP-1 to exert its effect, it requires NAD+ as its sole substrate(6,7). Thus, replenishment of NAD+ via supplementation is important in the prevention of damaged DNA replication and the initiation of DNA repair to protect cellular integrity(7). In addition, resveratrol and quercetin are potent antioxidants which protects cells and deters cell damage as well, complementing the actions of NAD+.
REFERENCES
Imai S, Guarente L. NAD+ and sirtuins in aging and disease. Trends in Cell Biology. 2014;24(8):464-471.
Croteau D, Fang E, Nilsen H, Bohr V. NAD+ in DNA repair and mitochondrial maintenance. Cell Cycle. 2017;16(6):491-492.
Guarente L. Linking DNA Damage, NAD+/SIRT1, and Aging. Cell Metabolism. 2014;20(5):706-707.
Belenky P, Racette F, Bogan K, McClure J, Smith J, Brenner C. Nicotinamide Riboside Promotes Sir2 Silencing and Extends Lifespan via Nrk and Urh1/Pnp1/Meu1 Pathways to NAD+. Cell. 2007;129(3):473-484.
Longo V, Kennedy B. Sirtuins in Aging and Age-Related Disease. Cell. 2006;126(2):257-268.
Javle M, Curtin N. The role of PARP in DNA repair and its therapeutic exploitation. British Journal of Cancer. 2011;105(8):1114-1122.
Surjana D, Halliday G, Damian D. Role of Nicotinamide in DNA Damage, Mutagenesis, and DNA Repair. Journal of Nucleic Acids. 2010;2010:1-13.